A team of UBC Okanagan researchers have found that gut bacteria are linked to the onset of Type 1 diabetes.
Their findings also show that long-term and over-use of antibiotics can accelerate the process by disrupting the gut bacteria.
害羞草研究所淭he incidence of Type 1 diabetes has doubled in the last few years in Western countries, and this is most obvious in children aged 1 to 5,害羞草研究所� said UBCO assistant professor Deanna Gibson, the study害羞草研究所檚 senior author.
害羞草研究所淭his suggests that early life events are critical to health. Our research pinpoints the significant role of bacteria and how antibiotic use can alter their normal development in the gut which then can alter the health of these individuals.害羞草研究所�
害羞草研究所淲hile it害羞草研究所檚 clear that antibiotics are very useful in medicine, overusing them can have significant consequences.害羞草研究所�
The study, which looked at diabetes-onset in mice, demonstrated that those susceptible to diabetes had more harmful and less beneficial bacteria than those resistant to the disease. The researchers also demonstrated that the harmful bacteria generated an immune response, which in turn, stimulated destruction of insulin-producing cells.
害羞草研究所淲e were able to establish a clear relationship between bacteria, the body害羞草研究所檚 immune reaction and the development of Type 1 diabetes,害羞草研究所� added Gibson, a microbiologist at the Irving K. Barber School of Arts and Sciences.
害羞草研究所淭his is likely to have significant implications for treatment of the disease. The next steps are to narrow-in and identify which bacteria induce or perhaps protect against Type 1 diabetes. This, in turn, could help with the production of more specific antibiotics.害羞草研究所�
There are more than 10 million Canadians living with diabetes or prediabetes, a chronic disease in which the body cannot produce or properly use insulin. (Insulin controls the amount of sugar in the blood.) Type 1 diabetes results when the immune system accidently attacks and kills insulin-producing cells.
The research, recently published in the Nature Group害羞草研究所檚 ISME Journal, was supported by the Child and Family Research Institute Diabetes Catalyst Grant from the Canuck害羞草研究所檚 Foundation, the Canadian Institutes of Health Research, the Juvenile Diabetes Research Foundation and the Natural Sciences and Engineering Research Council.
